Author: Supplefer

Iron is necessary for the creation of hemoglobin, the oxygen-carrying component of blood. Iron deficiency occurs when
there is an inadequate supply of iron to the body resulting from a low iron intake from the diet or losses of blood
from parasitic infections Deficiency may results in anemia due to low hemoglobin levels. Hemoglobin carries oxygen
to all cells and tissues in the body. A depletion of oxygen can cause loss of energy, decreased metabolism and a failure to thrive.

According to the World Health Organization, as many as 30% of the world’s population
has iron deficiency anemia and these rates are as high as 50% in children living in Africa and Asia (Foege; 2002). Iron deficiency anemia (IDA) is a leading cause of morbidity and mortality worldwide. Numerous studies have demonstrated that even moderate anemia (hemoglobin <100 g/L) is associated with depressed mental and motor development in …

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The minimum order size is 1 million sachets in bulk format. Organizations are responsible for the signing of a purchase agreement and the creation of custom artwork if different from the standard English/French version packaging design. Organizations may also wish to develop their own secondary packaging (i.e. box holding 20-30 sachets) for distribution to beneficiaries or consumers and are responsible for secondary packaging development, manufacturing and filling.

It is important to allow ample time for delivery. After the package artwork is approved, the estimated time to delivery is 12 weeks. The sachets are shipped in boxes of …

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PROCESS EVALUATION OF THE DISTRIBUTION OF MICRONUTRIENT SPRINKLES IN OVER 10,000 MONGOLIAN INFANTS USING A NON-GOVERNMENTAL ORGANIZATION (NGO) PROGRAM MODEL

C. Schauer, S. Zlotkin, M. Nyamsuren, C.R. Hubbell, M. Chan, O. Purevsuren, C. MacDonald, N. Klaas

Background: Economic instability and severe winters have resulted in food shortages across
Mongolia. As a result, micronutrient deficiencies (iron and vitamin D) are common among children.
‘Sprinkles’ containing iron and other micronutrients (including Vitamin D) were developed as an
inexpensive micronutrient supplement. Objectives 1. To determine the prevalence of anemia and
rickets in children <5 years. 2. To develop an NGO distribution model to deliver Sprinkles to
infants 6-36 mo. and achieve 80% coverage. 3. To monitor and evaluate process and biological
outcome indicators. Methods: A cross-sectional baseline survey was conducted among 1478 children.
Assessment of anemia was based on hemoglobin (Hb). Assessment of rickets was based on a physical
examination. Program design, …

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In 1996, a group of UNICEF consultants determined that available interventions for iron deficiency anemia (syrup and drops
for infants and children, and capsules for women) were not effective, as adherence to treatment remained poor. They called for a simple,
inexpensive and potentially viable new method to provide micronutrients (including iron) to populations at risk (UNICEF-monograph). This

was based on two observations from the ‘West’ where micronutrient deficiencies are rare; (a) fortification of commercially available
food provides
essential micronutrients and (b) no change in the color, texture or taste of the food ensures compliance.

Responding to the challenge, the Nutrition Research Group at The Hospital for Sick Children, University of Toronto, developed ‘Supplefer’ utilizing encapsulated micronutrients for adding directly to food, that is inexpensive to manufacture and distribute. The
encapsulate is a thin coating of lipid that prevents the iron from oxidizing the food, resulting in ‘no change’ in …

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The Intellectual Property Rights to Supplefer Sprinkles are owned by Ped Med Ltd., a private incorporated company owned by Stanley Zlotkin.

1. First rights of refusal for the intellectual property rights to sprinkles were offered to the Hospital for Sick Children (as per our contractual obligation with the hospital). The Hospital turned down the offer (1998) and thus the rights were taken up by us.

2. Intellectual property rights were taken up because we wanted to perform appropriate research on Sprinkles before they were generally distributed and because we wanted to control the content of Sprinkles and manage issues around quality control.

3. It has always been our intent to have Sprinkles distributed to the populations in most need of micronutrient supplements.

4. We have an agreement with the HJ Heinz Company such that they will provide technical support, assist in the manufacture of Sprinkles from various manufacturing facilities around …

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Mix the food well after you have added the package of Sprinkles

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Dr. Stanley Zlotkin received his medical training at McMaster University
and McGill and obtained a Ph.D. in Nutrition at the University of Toronto.
He has worked as a clinician-nutritionist and research scientist at the
Hospital for Sick Children since 1980. He is currently a Professor in the
Departments of Pediatrics and Nutritional Sciences at the University of
Toronto, a senior scientist in the Research Institute of the Hospital for
Sick Children, Medical Director of Nutrition Support at
The Hospital for Sick Children
Chief of the Division of Gastoenterology and Nutrition at the Hospital. He recently became a Research Fellow in the new
University of Toronto Centre for International Health.
As well as being a consultant on
nutritional issues to Canadian Federal and Provincial governments, he is
past Chair of the Nutrition Committee of the Canadian Paediatric Society
and past Chair of the Research Ethics Board of the Research Institute of…

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CTA (Clinical Trial Application)-Control#:074435 approved. This means that we are legally able to use “Sprinkles” in clinical trials within Canada.

DIN (Drug Identification Number)#:02244677 approved.

Owner: Ped-Med Ltd., 106 Kendal Avenue, Toronto, ON, Canada, M5R 1L9, fax: 416-813-4972

Name: Supplefer

Chemical Name: Ferrous Fumarate

Therapeutic Classification: Anemia Therapy

Pharmacological Classification: Minerals and Vitamins

Medicinal Ingredients: Iron (ferrous fumarate), Folic Acid, L-Ascorbic Acid, Zinc (Zinc Gluconate), Vitamin D3 (Cholecalciferol)

Non-medicinal Ingredients: Maltodextrin, Vitamin A

Dosage Form: Ferrous Fumarate and Micronutrient Powder in 0.5 mg Sachets…

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COMPLEMENTARY FOOD SUPPLEMENTS TO ACHIEVE MICRONUTRIENT ADEQUACY FOR INFANTS AND YOUNG CHILDREN
P. Nestel; A. Briend; B. de Benoist; E. Decker; E. Ferguson; O. Fontaine; A. Micardi; R. Nalubola

Many children in developing countries survive on a nutritionally inadequate diet. Dietary inadequacies during the complementary feeding period can be prevented by using complementary food supplements (CFSs) such as water dispersible or crushable micronutrient tablets, micronutrient sprinkles added to food just before feeding, or fortified spreads added to food just before feeding or fed as a snacks. A meeting was convened to discuss technical and operational issues related to the development of these new approaches and to identify knowledge gaps. The technical issues covered: what micronutrients to include, tolerable upper intake limits, bioavailability, micronutrient and macronutrient stability, package systems and amounts, encapsulation technologies, methods to limit or eliminate allergens, bacterial and chemical contamination, interactions between CFSs and complementary foods, and flavoring …

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In an effort to improve compliance to prevent iron deficiency anemia and other
micronutrient deficiencies, an alternate micronutrient delivery system for infants and
toddlers has been suggested by our group. This system involves a novel packaging method
and source of iron that is relatively inexpensive to manufacture and distribute. Essentially,
lipid encapsulated iron (soy-lipid) in powder form is packaged into individual sachets as a
single daily dose. Parents can be easily instructed to mix the contents of one sachet per
day into a bowl of any infant weaning food. Encapsulation of the iron source, ferrous fumarate,
prevents the iron from interacting with the food thereby preventing unacceptable organoleptic effects
associated with iron supplementation such as metallic-aftertaste and change of color, smell or texture
to foods. In vitro dissolution studies have demonstrated that the lipid encapsulate will
dissolve in the low pH of the stomach leaving the iron available for absorption. …

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